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Article

Structural interactomics: informatics approaches to aid the interpretation of genetic variation and the development of novel therapeutics.

Molecular bioSystems - 1 Dec 2009

Lee Semin, Brown Alan, Pitt William Ross, Higueruelo Alicia Perez, Gong Sungsam, Bickerton George Richard, Schreyer Adrian, Tanramluk Duangrudee, Baylay Alison, Blundell Tom Leon

Abstract excerpt

Here we review the use of informatics in structural interactomics, with particular emphasis on understanding interfacial contacts in the development of novel therapeutics and the interpretation of genetic variation. We describe the availability and applicability of structural databases of protein interactions which facilitate this endeavour. We demonstrate the applicability of a structural interactomics approach...

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PMID: 19763326
DOI: 10.1039/B906402h

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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