Absence of close linkage between maternal genes for susceptibility to pre-eclampsia/eclampsia and HLA DR beta.

doi:10.1016/0140-6736(90)92149-c

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Absence of close linkage between maternal genes for susceptibility to pre-eclampsia/eclampsia and HLA DR beta.

Lancet (London, England) - 15 Sept 1990

Wilton A N, Cooper D W, Brennecke S P, Bishop S M, Marshall P

Abstract excerpt

To test the possibility that maternally expressed susceptibility genes for pre-eclampsia/eclampsia are closely linked to the HLA region on chromosome 6 of the human genome, members of ten pedigrees with multiple cases of these disorders were typed for HLA DR beta restriction fragment length polymorphisms by means of TaqI digests. The data were analysed by the LIPED program to calculate lod scores, by several...

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Absence of close linkage between maternal genes for susceptibility to pre-eclampsia/eclampsia and HLA DR beta.

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