Article
Studies on the compatibility of HLA-Class II alleles in patient couples with severe pre-eclampsia using PCR-RFLP methods.
American journal of reproductive immunology (New York, N.Y. : 1989) - 1 Jul 2008
Ooki Izumi, Takakuwa Koichi, Akashi Mami, Nonaka Taro, Yokoo Tomokazu, Tanaka Kenichi
Abstract excerpt
PROBLEM: In this study, we investigated whether or not significant compatibility of human leukocyte antigen (HLA)-class II alleles exists between spouses with severe pre-eclampsia (PE) (including gestational hypertension, GH). METHOD OF STUDY: The HLA-class II genotypes were determined using a polymerase chain reaction-restriction fragment length polymorphism method. The number of incompatible alleles in 57...
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