Article
Association study on two vitamin D receptor gene polymorphisms and vitamin D metabolites in multiple sclerosis.
Annals of the New York Academy of Sciences - 1 Sept 2009
Smolders Joost, Damoiseaux Jan, Menheere Paul, Tervaert Jan Willem Cohen, Hupperts Raymond
Abstract excerpt
BACKGROUND: An association of two single-nucleotide polymorphisms (SNPs) of the vitamin D receptor (VDR) gene, Apal (rs7975232) and Taql (rs731236), with multiple sclerosis (MS) has been reported in a Caucasian population. Another SNP of the VDR gene, Fokl (rs10735810), has been associated with serum levels of 25-hydroxyvitamin D [25(OH)D]. OBJECTIVE: Since 25(OH)D status has been associated with MS incidence, we...
Read the complete abstract on PubMed