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Article

DKC1 overexpression associated with prostate cancer progression

15 Sept 2009

Abstract excerpt

BACKGROUND: Dyskerin encoded by the DKC1 gene is a predominantly nucleolar protein essential for the formation of pseudouridine in RNA and the telomerase RNA subunit hTR. Inherited mutations inactivating dyskerin cause dyskeratosis congenita, a syndrome with progeroid features characterised by skin defects and haematopoiesis failure, as well as cancer susceptibility. In this study, we report DKC1 overexpression...

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PMID: 19755982
DOI: 10.1038/sj.bjc.6605299

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