Article
HLA-D region genes associated with autoantibody responses to histidyl-transfer RNA synthetase (Jo-1) and other translation-related factors in myositis.
Arthritis and rheumatism - 1 Aug 1990
Goldstein R, Duvic M, Targoff I N, Reichlin M, McMenemy A M, Reveille J D, Warner N B, Pollack M S, Arnett F C
Abstract excerpt
Myositis has been associated with HLA-B8 and DR3, especially in white patients with polymyositis and serum anti-Jo-1 antibodies. Twenty-eight patients with myositis and serum translation-related autoantibodies anti-Jo-1, anti-PL-7, anti-PL-12, anti-KJ, and anti-SRP were studied for HLA class II specificities by Southern blotting with HLA-DR beta, DQ beta, and DQ alpha probes. The association of HLA-DR3 (DRw17)...
Topics
- Alleles
- Amino Acyl-tRNA Synthetases
- Antibodies, Antinuclear
- Autoantibodies
- Black People
- Genes
- HLA-DQ Antigens
- HLA-DR Antigens
- Histidine-tRNA Ligase
- Humans