Article
Pro12Ala polymorphism of the peroxisome proliferatoractivated receptor-gamma gene is associated with metabolic syndrome and surrogate measures of insulin resistance in healthy men: interaction with smoking status.
Circulation journal : official journal of the Japanese Circulation Society - 1 Nov 2009
Tellechea Mariana L, Aranguren Florencia, Pérez María Silvia, Cerrone Gloria E, Frechtel Gustavo D, Taverna Mariano J
Abstract excerpt
BACKGROUND: The Pro12Ala polymorphism (rs1801282), a nonsynonymous substitution of peroxisome proliferator-activated receptor-gamma (PPARG), has been robustly associated with type 2 diabetes. However, its role in metabolic syndrome (MetS) remains poorly understood. The associations among rs1801282, MetS and surrogate measures of insulin resistance (IR) were investigated in the present study. METHODS AND RESULTS:...
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