Article
An adaptive role for BDNF Val66Met polymorphism in motor recovery in chronic stroke.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 12 Feb 2014
Qin Luye, Jing Deqiang, Parauda Sarah, Carmel Jason, Ratan Rajiv R, Lee Francis S, Cho Sunghee
Abstract excerpt
Little is known about the influence of genetic diversity on stroke recovery. One exception is the polymorphism in brain derived neurotrophic factor (BDNF), a critical neurotrophin for brain repair and plasticity. Humans have a high-frequency single nucleotide polymorphism (SNP) in the prodomain of the BDNF gene. Previous studies show that the BDNF Val66Met variant negatively affects motor learning and severity of...
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