Article
Molecular analysis of carbohydrate N-acetylgalactosamine 4-O sulfotransferase 8 (CHST8) as a candidate gene for bovine spongiform encephalopathy susceptibility.
Animal genetics - 1 Feb 2010
Morina R, Knorr C, Haase B, Leeb T, Seuberlich T, Zurbriggen A, Brem G, Schütz E, Brenig B
Abstract excerpt
Endogenous prion proteins (PrP) play the central role in the pathogenesis of transmissible spongiform encephalopathies. The carbohydrate N-acetylgalactosamine 4-O sulfotransferase 8 (CHST8) promotes the conversion of the cellular PrP(C) into the pathogenic PrP(d). Six sequence variants within the...
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