Are cytochrome P4502D6 and apolipoprotein E genotypes associated with long-term cognitive and functional changes in patients treated with donepezil?

doi:10.1111/psyg.12547

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Are cytochrome P4502D6 and apolipoprotein E genotypes associated with long-term cognitive and functional changes in patients treated with donepezil?

Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society - 1 Sept 2020

Pamio Maria V, Trevisan Caterina, Pigozzo Sabrina, De Rui Marina, Devita Maria, Girardi Agostino, Manzato Enzo, Sergi Giuseppe, Coin Alessandra

Abstract excerpt

AIM: We investigated the associations of the single-nucleotide polymorphism rs1080985 of cytochrome P4502D6 (CYP2D6) and the apolipoprotein E (APOE) genotypes with cognitive and functional changes in patients treated with donepezil. METHODS: Sixty-five outpatients with Alzheimer's disease or mixed dementia being treated with donepezil were assessed at baseline and over 27 months. Changes in cognitive status,...

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PMID: 32237281
DOI: 10.1111/psyg.12547

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