Article
Identification of a new genomic hot spot of evolutionary diversification of protein function.
PloS one - 1 Jan 2015
Winkelmann Aline, You Xiantian, Grünewald Nora, Häussler Ute, Krestel Heinz, Haas Carola A, Schwarz Günter, Chen Wei, Meier Jochen C
Abstract excerpt
Establishment of phylogenetic relationships remains a challenging task because it is based on computational analysis of genomic hot spots that display species-specific sequence variations. Here, we identify a species-specific thymine-to-guanine sequence variation in the Glrb gene which gives rise to species-specific splice donor sites in the Glrb genes of mouse and bushbaby. The resulting splice insert in the...
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