Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Beta-adrenoceptor metabolism in wild-type, Gs, and protein kinase A-variant S49 cells.

The American journal of physiology - 1 Jul 1990

Jasper J R, Motulsky H J, Mahan L C, Insel P A

Abstract excerpt

To determine the role of the stimulatory guanine nucleotide-binding protein, Gs, and adenosine 3',5'-cyclic monophosphate (cAMP)-dependent protein kinase in the basal metabolism of beta-adrenergic receptors in S49 lymphoma cells, we measured the return of receptor number and function after irreversible blockade of receptors. After inactivation of receptors with the irreversible ligand...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding, Competitive
Share to Cell Line
Share to Clone Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Kinetics

Share to Protein Kinases

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 1973600
DOI: 10.1152/ajpcell.1990.259.1.C41

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Beta-adrenoceptor metabolism in wild-type, Gs, and protein kinase A-variant S49 cells.PMID 1973600Read ↗

Decreased transcript expression coincident with impaired glycosylation in the beta2-adrenergic receptor gene does not result from differences in the primary sequence.Semantic proximity Read ↗

Regulatory properties of alpha(1B)-adrenergic receptors defective in coupling to phosphoinositide hydrolysis.Semantic proximity Read ↗

Intact cell binding properties of cells expressing altered beta-adrenergic receptors.Semantic proximity Read ↗

Decreased beta 2-adrenergic receptor mRNA expression in receptor-deficient S49 lymphoma cells.Semantic proximity Read ↗

Prolonged activation of inhibitory somatostatin receptors increases adenylate cyclase activity in wild-type and Gs alpha-deficient (cyc-) S49 mouse lymphoma cells.Semantic proximity Read ↗

Activation of the alpha subunit of Gs in intact cells alters its abundance, rate of degradation, and membrane avidity.Semantic proximity Read ↗

Altered G protein activity in a desensitization-resistant mutant of the Y1 adrenocortical tumor cell line.Semantic proximity Read ↗

Second-site mutations in cyclic AMP-sensitive revertants of a Ka mutant of S49 mouse lymphoma cells reduce the affinity of regulatory subunit of cyclic AMP-dependent protein kinase for catalytic subunit.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.