Article
Decreased beta 2-adrenergic receptor mRNA expression in receptor-deficient S49 lymphoma cells.
Molecular pharmacology - 1 Dec 1991
Hughes R J, Howard M J, Allen J M, Insel P A
Abstract excerpt
Many variants of the S49 mouse lymphoma cell have been isolated along the pathway of cyclic AMP generation and response. Two such variants, beta p and beta d, were isolated by Johnson and colleagues and described in 1979 [Mol. Pharmacol. 15:16-27 (1979)]. The beta p and beta d variants express one half and one quarter, respectively, of the wild-type number of beta 2-adrenergic receptors. This observation has now...
Topics
- Animals
- Base Sequence
- Gene Expression
- Lymphoma
- Mice
- Molecular Sequence Data
- Phenotype
- RNA, Messenger
- Receptors, Adrenergic, beta
- Tumor Cells, Cultured