Article
Telomere attrition and telomerase activity are associated with GSTM1 polymorphism in oral cancer.
Cancer biomarkers : section A of Disease markers - 1 Jan 2009
Sainger Rachana N, Shah Franky D, Telang Shaila D, Shah Pankaj M, Patel Prabhudas S
Abstract excerpt
Telomere attrition is an important event during tumorigenesis regulated by factors including oxidative stress, mitochondrial function, DNA adducts etc. Critically short telomeres act as signal for telomerase activity in the cancer cells. To determine whether null genotype of GSTM1 gene has any association with telomere length shortening and telomerase activity, we analyzed telomere length, telomerase activity and...
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