Article
The role of TERT-CLPTM1L SNPs, hTERT expression and telomere length in the pathogenesis of oral squamous cell carcinoma.
Journal of oral science - 1 Jan 2016
Carkic Jelena, Nikolic Nadja, Radojevic-Skodric Sanja, Kuzmanovic-Pficer Jovana, Brajovic Gavrilo, Antunovic Marija, Milasin Jelena, Popovic Branka
Abstract excerpt
The aim of this study was to assess TERT-CLPTM1L single-nucleotide polymorphisms (SNPs) (rs402710 C/T in the CLPTM1L gene; rs2736100 A/C and rs2736098 G/A in the TERT gene) as risk factors for development of oral squamous cell carcinoma (OSCC), and to investigate the relationship between the analyzed polymorphisms, relative telomere length (RTL), telomerase expression and clinicopathologic characteristics of OSCC...
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