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Article

Alport syndrome mutations in type IV tropocollagen alter molecular structure and nanomechanical properties.

Journal of structural biology - 1 Dec 2009

Srinivasan Maya, Uzel Sebastien G M, Gautieri Alfonso, Keten Sinan, Buehler Markus J

Abstract excerpt

Alport Syndrome is a genetic disease characterized by breakdown of the glomerular basement membrane (GBM) around blood vessels in the kidney, leading to kidney failure in most patients. It is the second most inherited kidney disease in the US, and many other symptoms are associated with the disease, including hearing loss and ocular lesions. Here we probe the molecular level structure-property relationships of...

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Identifiers

PMID: 19729067
DOI: 10.1016/j.jsb.2009.08.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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