Article
DNA polymorphisms of the apolipoprotein B gene in patients with premature coronary artery disease.
Atherosclerosis - 1 May 1990
Genest J J, Ordovas J M, McNamara J R, Robbins A M, Meade T, Cohn S D, Salem D N, Wilson P W, Masharani U, Frossard P M
Abstract excerpt
Elevated plasma levels of low density cholesterol and their major apolipoprotein (apo B) are associated with an increased risk of coronary artery disease (CAD). We have examined allele frequencies of restriction fragment length polymorphisms (RFLP) of the apo B gene in 111 male Caucasians with premature CAD (mean age 49 +/- 7 years) and in 122 elderly Caucasian males (mean age, 73 +/- 5 years), free of clinical...
Topics
- Adult
- Aged
- Alleles
- Apolipoproteins B
- Cholesterol, HDL
- Cholesterol, LDL
- Coronary Disease
- DNA
- Enzyme-Linked Immunosorbent Assay
- Genotype
- Humans