Article
The MspI restriction fragment length polymorphism 3' to the apolipoprotein A-II gene: relationships with lipids, apolipoproteins, and premature coronary artery disease.
Atherosclerosis - 1 Feb 1992
Civeira F, Genest J, Pocovi M, Salem D N, Herbert P N, Wilson P W, Schaefer E J, Ordovas J M
Abstract excerpt
In previous studies, a restriction fragment length polymorphism (RFLP) has been identified using MspI restriction endonuclease in the 3' region of the apo A-II gene. The rare variant site for this MspI (M2) has been reported to be associated with higher levels of HDL cholesterol and apo A-II. We have studied the frequency and lipid associations of this RFLP in a population of 168 coronary artery disease (CAD)...
Topics
- Adult
- Age Factors
- Alleles
- Apolipoprotein A-II
- Apolipoproteins
- Base Sequence
- Coronary Disease
- DNA
- DNA Mutational Analysis
- Female
- Genetic Linkage