Both HLA class II and class III DNA polymorphisms are linked to juvenile rheumatoid arthritis susceptibility.

doi:10.1016/0090-1229(90)90165-m

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Article

Both HLA class II and class III DNA polymorphisms are linked to juvenile rheumatoid arthritis susceptibility.

Clinical immunology and immunopathology - 1 Jul 1990

Vicario J L, Martinez-Laso J, Gomez-Reino J J, Gomez-Reino F J, Regueiro J R, Corell A, Segurado O G, Arnaiz-Villena A

Abstract excerpt

HLA-DR5 and DRw8 are not significantly linked to juvenile rheumatoid arthritis (JRA) in the Spanish population. However, we have found restriction fragment length polymorphisms (RFLPs) beta DR-2.9-kb-EcoRI and C4-14.3-kb-EcoRI, that correlate significantly with JRA. Eighty-six percent of our pati...

Topics

Arthritis, Juvenile
Biomarkers
Child
Deoxyribonuclease EcoRI
Female
Genetic Predisposition to Disease
HLA Antigens
HLA-D Antigens
Humans
Male
Polymorphism, Restriction Fragment Length
Spain

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Open in PubMed

Identifiers

PMID: 1972672
DOI: 10.1016/0090-1229(90)90165-m

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1972672-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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