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Article

Promoter variants of the cannabinoid receptor 1 gene (CNR1) in interaction with 5-HTTLPR affect the anxious phenotype.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Dec 2009

Lazary Judit, Lazary Aron, Gonda Xenia, Benko Anita, Molnar Eszter, Hunyady Laszlo, Juhasz Gabriella, Bagdy Gyorgy

Abstract excerpt

Anxiety is a polygenic condition, and the recently discovered Endocannabinoid System (ECS) is one plausible candidate. Experimental data suggest that the ECS can modulate several neurotransmitter systems, including the serotonergic system, which itself plays a significant role in anxiety. However, to date there is no evidence of gene-gene interactions; indeed genetic studies focusing separately on the two systems...

Read the complete abstract on PubMed

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Share to Anxiety
Share to Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Genetic

Share to Promoter Regions, Genetic

Share to Psychiatric Status Rating Scales

Share to Receptor, Cannabinoid, CB1

Share to Serotonin Plasma Membrane Transport Proteins

Share to Young Adult

Source

Identifiers

PMID: 19725030
DOI: 10.1002/ajmg.b.31024

Genes

CNR1
HTT

Provenance

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