Article
The prevalence of uridine diphosphate-glucuronosyltransferase 1A9 (UGT1A9) gene promoter region single-nucleotide polymorphisms T-275A and C-2152T and its influence on mycophenolic acid pharmacokinetics in stable renal transplant patients.
Transplantation proceedings - 1 Jan 2000
Sánchez-Fructuoso A I, Maestro M L, Calvo N, Viudarreta M, Pérez-Flores I, Veganzone S, De la Orden V, Ortega D, Arroyo M, Barrientos A
Abstract excerpt
UNLABELLED: The aim of this study was to evaluate the distribution of UGT1A9 promoter region T-275A and C-2152T single nucleotide polymorphisms (SNPs) in stable transplant patients and to investigate the impact of these SNPs on mycophenolic acid (MPA) pharmacokinetics. METHODS: In total, 133 Caucasian renal transplant recipients were studied. Also a complete 12-hour pharmacokinetic profile was recorded for 15...
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