Article
Interethnic differences in the distribution of clinically relevant vascular endothelial growth factor genetic polymorphisms.
DNA and cell biology - 1 Nov 2009
Muniz Jaqueline J, Izidoro-Toledo Tatiane C, Metzger Ingrid F, Sandrim Valeria C, Tanus-Santos Jose E
Abstract excerpt
Vascular endothelial growth factor (VEGF) is a homodimeric glycoprotein produced mostly in endothelial cells and its transcription is regulated by a variety of growth factors and cytokines. VEGF plays many relevant roles, and three functional polymorphisms in the promoter region of the VEGF gene (C-2578A, G-1154A, and G-634C) have been associated with disease conditions. Although some studies suggest that...
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