Article
Evidence of association of serotonin transporter gene polymorphisms with schizophrenia in a South Indian population.
Journal of human genetics - 1 Sept 2009
Vijayan Neetha N, Iwayama Yoshimi, Koshy Linda V, Natarajan Chandrasekhar, Nair Chandrashekharan, Allencherry Priya M, Yoshikawa Takeo, Banerjee Moinak
Abstract excerpt
Serotonin (5-hydroxytryptamine (5-HT)) transporter (SLC6A4) is known to influence mood, emotion, cognition and efficacy of antidepressants, particularly that of selective serotonin reuptake inhibitors. Atypical antipsychotics exert their effects partially through serotinergic systems, and hence, variation in 5-HT uptake may affect antipsychotic action mediated through the serotinergic system. Therefore,...
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