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Article

Recruitment and positioning determine the specific role of the XPF-ERCC1 endonuclease in interstrand crosslink repair.

The EMBO journal - 14 Jul 2017

Klein Douwel Daisy, Hoogenboom Wouter S, Boonen Rick Acm, Knipscheer Puck

Abstract excerpt

XPF-ERCC1 is a structure-specific endonuclease pivotal for several DNA repair pathways and, when mutated, can cause multiple diseases. Although the disease-specific mutations are thought to affect different DNA repair pathways, the molecular basis for this is unknown. Here we examine the function of XPF-ERCC1 in DNA interstrand crosslink (ICL) repair. We used Xenopus egg extracts to measure both ICL and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28292785
DOI: 10.15252/embj.201695223
PMCID: PMC5510004

Genes

ERCC1
SLX4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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Recruitment and positioning determine the specific role of the XPF-ERCC1 endonuclease in interstrand crosslink repair.PMID 28292785Read ↗

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ERCC1-XPF Endonuclease Facilitates DNA Double-Strand Break RepairSemantic proximity Read ↗

The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-links.Semantic proximity Read ↗

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