Article
Serotonin-related FEV gene variant in the sudden infant death syndrome is a common polymorphism in the African-American population.
Pediatric research - 1 Dec 2009
Broadbelt Kevin G, Barger Melissa A, Paterson David S, Holm Ingrid A, Haas Elisabeth A, Krous Henry F, Kinney Hannah C, Markianos Kyriacos, Beggs Alan H
Abstract excerpt
An important subset of the sudden infant death syndrome (SIDS) is associated with multiple serotonergic (5-HT) abnormalities in regions of the medulla oblongata. The mouse ortholog of the fifth Ewing variant gene (FEV) is critical for 5-HT neuronal development. A putatively rare intronic variant [IVS2-191_190insA, here referred to as c.128-(191_192)dupA] has been reported as a SIDS-associated mutation in an...
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