Article
Vitamin D receptor and calcium sensing receptor polymorphisms and the risk of colorectal cancer in European populations.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Sept 2009
Jenab Mazda, McKay James, Bueno-de-Mesquita Hendrik B, van Duijnhoven Franzel J B, Ferrari Pietro, Slimani Nadia, Jansen Eugène H J M, Pischon Tobias, Rinaldi Sabina, Tjønneland Anne, Olsen Anja, Overvad Kim, Boutron-Ruault Marie-Christine, Clavel-Chapelon Françoise, Engel Pierre, Kaaks Rudolf, Linseisen Jakob, Boeing Heiner, Fisher Eva, Trichopoulou Antonia, Dilis Vardis, Oustoglou Erifili, Berrino Franco, Vineis Paolo, Mattiello Amalia, Masala Giovanna, Tumino Rosario, Vrieling Alina, van Gils Carla H, Peeters Petra H, Brustad Magritt, Lund Eiliv, Chirlaque María-Dolores, Barricarte Aurelio, Suárez Laudina Rodríguez, Molina Esther, Dorronsoro Miren, Sala Núria, Hallmans Göran, Palmqvist Richard, Roddam Andrew, Key Timothy J, Khaw Kay-Tee, Bingham Sheila, Boffetta Paolo, Autier Philippe, Byrnes Graham, Norat Teresa, Riboli Elio
Abstract excerpt
Increased levels of vitamin D and calcium may play a protective role in colorectal cancer (CRC) risk. It has been suggested that these effects may be mediated by genetic variants of the vitamin D receptor (VDR) and the calcium sensing receptor (CASR). However, current epidemiologic evidence from European populations for a role of these genes in CRC risk is scarce. In addition, it is not clear whether these genes...
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