Article
ATP13A2 variants in early-onset Parkinson's disease patients and controls.
Movement disorders : official journal of the Movement Disorder Society - 30 Oct 2009
Djarmati Ana, Hagenah Johann, Reetz Kathrin, Winkler Susen, Behrens Maria Isabel, Pawlack Heike, Lohmann Katja, Ramirez Alfredo, Tadić Vera, Brüggemann Norbert, Berg Daniela, Siebner Hartwig R, Lang Anthony E, Pramstaller Peter P, Binkofski Ferdinand, Kostić Vladimir S, Volkmann Jens, Gasser Thomas, Klein Christine
Abstract excerpt
Four genes responsible for recessively inherited forms of Parkinson's disease (PD) have been identified, including the recently discovered ATP13A2 (PARK9) gene. Our objective was to investigate the role of this gene in a large cohort of PD patients and controls. We extensively screened all 29 exons of the ATP13A2 coding region in 112 patients with early-onset PD (EOPD; <40 years) of mostly European ethnic origin...
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