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Microfluidic single cell arrays to interrogate signalling dynamics of individual, patient-derived hematopoietic stem cells

1 Jan 2009

Abstract excerpt

Stem cells hold great promise as a means of treating otherwise incurable, degenerative diseases due to their ability both to self-renew and differentiate. However, stem cell damage can also play a role in the disease with the formation of solid tumors and leukaemias such as chronic myeloid leukaemia (CML), a hematopoietic stem cell (HSC) disorder. Despite recent medical advances, CML remains incurable by drug...

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PMID: 19704981
DOI: 10.1039/b902083g

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