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Article

Label-free microfluidic chip for segregation and recovery of circulating leukemia cells: clinical applications in acute myeloid leukemia.

Biomedical microdevices - 12 Dec 2023

Ouyang Dongfang, Ye Ningxin, Jiang Yue, Wang Yiyang, Hu Lina, Chao Shuen, Yarmush Martin, Tuner Memet, Li Yonghua, Tang Bin

Abstract excerpt

We present a label-free microfluidic chip for the segregation of circulating leukemia cells (CLCs) from blood samples, with a focus on its clinical applications in Acute Myeloid Leukemia (AML). The microfluidic chip achieved an approximate capture efficiency of 92%. The study analyzed a comprehensive set of 66 blood specimens from AML patients in different disease stages, including newly diagnosed and relapsing...

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PMID: 38085348
DOI: 10.1007/s10544-023-00687-7

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