Article
Possible gene-gene interaction of KIR2DL4 with its cognate ligand HLA-G in modulating risk for preeclampsia.
Reproductive sciences (Thousand Oaks, Calif.) - 1 Dec 2009
Tan Chia Yee, Chong Yap Seng, Loganath Annamalai, Chan Yiong Huak, Ravichandran Jeganathan, Lee Caroline G, Chong Samuel S
Abstract excerpt
Preeclampsia (PE) is a leading cause of maternal and fetal mortality and morbidity that occurs only during pregnancy. Pregnancy is the only physiological situation where killer-cell immunoglobulin-like receptors (KIRs) may meet cognate nonself variants of human leukocyte antigen (HLA) allotypes. We previously reported that presence of fetal HLA-G*0106 was significantly associated with risk for PE in multigravid...
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