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Article

Single nucleotide polymorphism in ABCG2 is associated with irinotecan-induced severe myelosuppression.

Journal of human genetics - 1 Oct 2009

Cha Pei-Chieng, Mushiroda Taisei, Zembutsu Hitoshi, Harada Hiromasa, Shinoda Noriyuki, Kawamoto Shunji, Shimoyama Rai, Nishidate Toshihiko, Furuhata Tomohisa, Sasaki Kazuaki, Hirata Koichi, Nakamura Yusuke

Abstract excerpt

Irinotecan is an anti-neoplastic agent that is widely used for treating colorectal and lung cancers, but often causes toxicities such as severe myelosuppression and diarrhea. In this study, we performed a two-stage case-control association study for irinotecan-induced severe myelosuppression (grades 3 and 4). In the first stage, 23 patients who developed severe myelosuppression and 58 patients who did not develop...

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Share to Antineoplastic Agents, Phytogenic
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Source

Identifiers

PMID: 19696792
DOI: 10.1038/jhg.2009.80

Genes

ABCG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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