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Article

Design and evaluation of new analogs of the sweet protein brazzein.

Chemical senses - 1 Oct 2009

Walters D Eric, Cragin Tiffany, Jin Zheyuan, Rumbley Jon N, Hellekant Göran

Abstract excerpt

We have previously modeled the interaction of the sweet protein brazzein with the extracellular domains of the sweet taste receptor. Here, we describe the application of that model to the design of 12 new highly potent analogs of brazzein. Eight of the 12 analogs have higher sweetness potency than wild-type brazzein. Results are consistent with our brazzein-receptor interaction model. The model predicts binding...

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Identifiers

PMID: 19696120
DOI: 10.1093/chemse/bjp048
PMCID: PMC2745351

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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