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Article

Structure-function relationships of brazzein variants with altered interactions with the human sweet taste receptor.

Protein science : a publication of the Protein Society - 1 Mar 2016

Singarapu Kiran K, Tonelli Marco, Markley John L, Assadi-Porter Fariba M

Abstract excerpt

Brazzein (Brz) is a small (54 amino acid residue) sweet tasting protein with physical and taste properties superior to other non-carbohydrate sweeteners. In an investigation of sequence-dependent functional properties of the protein, we used NMR spectroscopy to determine the three-dimensional structures and dynamic properties of two Brz variants: one with a single-site substitution (D40K), which is three-fold...

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Identifiers

PMID: 26701738
DOI: 10.1002/pro.2870
PMCID: PMC4815422

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