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Article

DNA polymorphisms of the alpha 1-antitrypsin gene region in patients with chronic obstructive pulmonary disease.

European journal of clinical investigation - 1 Feb 1990

Poller W, Meisen C, Olek K

Abstract excerpt

Alpha 1-antitrypsin (AAT) is an important part of the defence mechanism of the lung against proteolytic attack. The Z and Null mutants of the AAT gene are associated with very low or missing serum concentrations of AAT, so that for individuals with genotypes ZZ or Null there is a very high risk of developing chronic obstructive pulmonary disease (COPD). In more than 90% of the patients suffering from COPD,...

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Identifiers

PMID: 1969347
DOI: 10.1111/j.1365-2362.1990.tb01769.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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