Article
Independent mutations in the flanking sequence of the alpha-1-antitrypsin gene are associated with chronic obstructive airways disease.
Disease markers - 1 Jan 2000
Kalsheker N A, Watkins G L, Hill S, Morgan K, Stockley R A, Fick R B
Abstract excerpt
Two restriction fragment length polymorphisms (RFLPs) of the flanking sequence of the alpha 1-antitrypsin (AAT) gene, detected with the restriction enzymes HindIII and TaqI, have been reported to occur more commonly in patients with chronic obstructive airways disease (COAD). Their frequencies were investigated in 20 Caucasian families with a family history of COAD and in 140 unrelated COAD patients none of whom...
Topics
- Adolescent
- Adult
- Aged
- Child
- Deoxyribonuclease HindIII
- Deoxyribonucleases, Type II Site-Specific
- Disease Susceptibility
- Female
- Genetic Markers
- Haplotypes
- Humans