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Article

Alpha 1-antitrypsin alleles in patients with pulmonary emphysema, detected by DNA amplification (PCR) and oligonucleotide probes.

The European respiratory journal - 1 May 1992

Bruun-Petersen K, Bruun-Petersen G, Dahl R, Larsen B, Kølvraa S, Koch J, Bolund L, Gregersen N

Abstract excerpt

Alpha 1-antitrypsin (AAT) deficiency is a serious predisposing factor for the development of pulmonary emphysema. Twelve representative Danish families were studied. AAT typing was performed as a comparative study between the traditional protein typing by isoelectrical focusing and the deoxyribonucleic acid (DNA) technique of enzymatic amplification and subsequent typing with radioactively labelled...

Topics

Adult
Alleles
Base Sequence
Female
Genotype
Humans
Isoelectric Focusing
Male
Molecular Sequence Data
Oligonucleotide Probes
Pedigree

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Polymerase Chain Reaction

Pulmonary Emphysema

alpha 1-Antitrypsin

alpha 1-Antitrypsin Deficiency

Source

Identifiers

PMID: 1612154

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1612154-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Alpha 1-antitrypsin alleles in patients with pulmonary emphysema, detected by DNA amplification (PCR) and oligonucleotide probes.PMID 1612154Read ↗

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