Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evaluation of the Role of Hexokinase Type II in Cellular Proliferation and Apoptosis Using Human Hepatocellular Carcinoma Cell Lines

18 Aug 2009

Abstract excerpt

UNLABELLED: The (18)F-FDG uptake pattern on PET could be an indicator of the prognosis and aggressiveness of various tumors, including hepatocellular carcinoma (HCC). Hexokinase, especially hexokinase type II (HKII), plays a critical role in (18)F-FDG uptake in rapidly growing tumors. We established a stable cell line overexpressing HKII by the transfection of full DNA of HKII to HCC cells (SNU449) that express...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alkaline Phosphatase Research Studies
Share to Cancer, Hypoxia, and Metabolism
Share to Glycogen Storage Diseases and Myoclonus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19690031
DOI: 10.2967/jnumed.108.060780

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evaluation of the Role of Hexokinase Type II in Cellular Proliferation and Apoptosis Using Human Hepatocellular Carcinoma Cell LinesPMID 19690031Read ↗

The Roles of HK2 on Tumorigenesis of Cervical CancerSemantic proximity Read ↗

Hexokinase 1b is a novel target for Non–small-cell lung cancerSemantic proximity Read ↗

STAT3 regulates glycolysis via targeting hexokinase 2 in hepatocellular carcinoma cellsSemantic proximity Read ↗

Aberrant glycolytic metabolism of cancer cells: a remarkable coordination of genetic, transcriptional, post-translational, and mutational events that lead to a critical role for type II hexokinase.Semantic proximity Read ↗

Unlocking the Potential of HK2 in Cancer Metabolism and TherapeuticsSemantic proximity Read ↗

Inhibition of glycolytic enzyme hexokinase II (HK2) suppresses lung tumor growthSemantic proximity Read ↗

Glucose catabolism in cancer cells: identification and characterization of a marked activation response of the type II hexokinase gene to hypoxic conditions.Semantic proximity Read ↗

PIM2-mediated phosphorylation of hexokinase 2 is critical for tumor growth and paclitaxel resistance in breast cancerSemantic proximity Read ↗

Regulation and cytoprotective role of hexokinase III.Semantic proximity Read ↗

Aberrant expression of the glycolytic enzymes aldolase B and type II hexokinase in hepatocellular carcinoma are predictive markers for advanced stage, early recurrence and poor prognosis.Semantic proximity Read ↗

The effect of 3-bromopyruvate on human colorectal cancer cells is dependent on glucose concentration but not hexokinase II expressionSemantic proximity Read ↗

Targeting hexokinase 2 to induce breast cancer cell senescenceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.