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Article

Pancreatic endocrine microadenomatosis in patients with von Hippel-Lindau disease: characterization by VHL/HIF pathway proteins expression.

The American journal of surgical pathology - 1 May 2009

Périgny Martine, Hammel Pascal, Corcos Olivier, Larochelle Olivier, Giraud Sophie, Richard Stéphane, Sauvanet Alain, Belghiti Jacques, Ruszniewski Philippe, Bedossa Pierre, Couvelard Anne

Abstract excerpt

INTRODUCTION: Von Hippel-Lindau (VHL) disease is an inherited syndrome caused by germline mutation in the VHL tumor suppressor gene predisposing to pancreatic endocrine tumors (PET). Whether these tumors derive from preexisting endocrine microadenomatosis as in multiple endocrine neoplasia type 1 (MEN1) is yet unknown. pVHL regulates hypoxia-inducible factor (HIF) that causes transcription activity of target...

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Source

Identifiers

PMID: 19238077
DOI: 10.1097/PAS.0b013e3181967992

Genes

VHL
MEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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