Article
alpha-1-syntrophin mutation and the long-QT syndrome: a disease of sodium channel disruption.
Circulation. Arrhythmia and electrophysiology - 1 Aug 2008
Wu Geru, Ai Tomohiko, Kim Jeffrey J, Mohapatra Bhagyalaxmi, Xi Yutao, Li Zhaohui, Abbasi Shahrzad, Purevjav Enkhsaikhan, Samani Kaveh, Ackerman Michael J, Qi Ming, Moss Arthur J, Shimizu Wataru, Towbin Jeffrey A, Cheng Jie, Vatta Matteo
Abstract excerpt
BACKGROUND: Long-QT syndrome (LQTS) is an inherited disorder associated with sudden cardiac death. The cytoskeletal protein syntrophin-alpha(1) (SNTA1) is known to interact with the cardiac sodium channel (hNa(v)1.5), and we hypothesized that SNTA1 mutations might cause phenotypic LQTS in patient...
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