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Article

Global methylation silencing of clustered <i>proto‐cadherin</i> genes in cervical cancer: serving as diagnostic markers comparable to HPV

21 Nov 2014

Abstract excerpt

Epigenetic remodeling of cell adhesion genes is a common phenomenon in cancer invasion. This study aims to investigate global methylation of cell adhesion genes in cervical carcinogenesis and to apply them in early detection of cancer from cervical scraping. Genome-wide methylation array was performed on an investigation cohort, including 16 cervical intraepithelial neoplasia 3 (CIN3) and 20 cervical cancers (CA)...

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PMID: 25418975
DOI: 10.1002/cam4.335

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