Article
Tissue effect on genetic control of transcript isoform variation.
PLoS genetics - 1 Aug 2009
Kwan Tony, Grundberg Elin, Koka Vonda, Ge Bing, Lam Kevin C L, Dias Christel, Kindmark Andreas, Mallmin Hans, Ljunggren Osten, Rivadeneira Fernando, Estrada Karol, van Meurs Joyce B, Uitterlinden Andre, Karlsson Magnus, Ohlsson Claes, Mellström Dan, Nilsson Olle, Pastinen Tomi, Majewski Jacek
Abstract excerpt
Current genome-wide association studies (GWAS) are moving towards the use of large cohorts of primary cell lines to study a disease of interest and to assign biological relevance to the genetic signals identified. Here, we use a panel of human osteoblasts (HObs) to carry out a transcriptomic survey, similar to recent studies in lymphoblastoid cell lines (LCLs). The distinct nature of HObs and LCLs is reflected by...
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