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Article

Conditional Deletion of <i>Dnaic1</i> in a Murine Model of Primary Ciliary Dyskinesia Causes Chronic Rhinosinusitis

12 Aug 2009

Abstract excerpt

Studies of primary ciliary dyskinesia (PCD) have been hampered by the lack of a suitable animal model because disruption of essential ciliary genes in mice results in a high incidence of lethal hydrocephalus. To develop a viable mouse model for long-term studies of PCD, we have generated a transgenic mouse line in which two conserved exons of the mouse intermediate dynein chain gene, Dnaic1, are flanked by loxP...

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Identifiers

PMID: 19675306
DOI: 10.1165/rcmb.2009-0118oc

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