Article
Cardiovascular response to beta-adrenergic blockade or activation in 23 inbred mouse strains.
PloS one - 12 Aug 2009
Berthonneche Corinne, Peter Bastian, Schüpfer Fanny, Hayoz Pamela, Kutalik Zoltán, Abriel Hugues, Pedrazzini Thierry, Beckmann Jacques S, Bergmann Sven, Maurer Fabienne
Abstract excerpt
We report the characterisation of 27 cardiovascular-related traits in 23 inbred mouse strains. Mice were phenotyped either in response to chronic administration of a single dose of the beta-adrenergic receptor blocker atenolol or under a low and a high dose of the beta-agonist isoproterenol and compared to baseline condition. The robustness of our data is supported by high trait heritabilities (typically...
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