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Article

Assessment of binding affinity to 5-hydroxytryptamine 2A (5-HT2A) receptor and inverse agonist activity of naftidrofuryl: comparison with those of sarpogrelate.

Journal of pharmacological sciences - 1 Aug 2009

Aly Saida Abdel Regal, Hossain Murad, Bhuiyan Mohiuddin Ahmed, Nakamura Takashi, Nagatomo Takafumi

Abstract excerpt

Naftidrofuryl is a peripheral vasodilator that has been clinically used in the treatment of intermittent claudication and dementia. It has 5-hydroxytryptamine 2 (5-HT(2)) antiserotonergic activity and selectively binds with the 5-HT(2) receptor. The purpose of the present study is to assess the binding affinity and functional potency of naftidrofuryl to the 5-HT(2A) receptor, to find out the inverse agonist...

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Identifiers

PMID: 19672037
DOI: 10.1254/jphs.09124fp

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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