Article
Hairy cell leukemias with unmutated IGHV genes define the minor subset refractory to single-agent cladribine and with more aggressive behavior.
Blood - 19 Nov 2009
Forconi Francesco, Sozzi Elisa, Cencini Emanuele, Zaja Francesco, Intermesoli Tamara, Stelitano Caterina, Rigacci Luigi, Gherlinzoni Filippo, Cantaffa Renato, Baraldi Anna, Gallamini Andrea, Zaccaria Alfonso, Pulsoni Alessandro, Gobbi Marco, Tassi Maristella, Raspadori Donatella, Leoncini Lorenzo, Rinaldi Andrea, Sabattini Elena, Bertoni Francesco, Pileri Stefano A, Lauria Francesco
Abstract excerpt
Hairy cell leukemia (HCL) is generally responsive to single-agent cladribine, and only a minority of patients are refractory and with poor prognosis. HCLs generally express mutated (M) and, in a minority, unmutated (UM) IGHV. In a multicenter clinical trial in newly diagnosed HCL, we prospectivel...
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