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Article

NPHS2 gene polymorphism aggravates renal damage caused by focal segmental glomerulosclerosis with COL4A3 mutation.

Bioscience reports - 29 Jan 2021

Sun Liping, Zhang Xinzhou, Wang Zhen

Abstract excerpt

Focal segmental glomerulosclerosis (FSGS), a type of primary glomerular disease, is the leading cause of end-stage renal disease (ESRD). Several studies have revealed that certain single-gene mutations are involved in the pathogenesis of FSGS; however, the main cause of FSGS has not been fully elucidated. Homozygous mutations in the glomerular basement membrane gene can lead to early renal failure, while...

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Identifiers

PMID: 33305316
DOI: 10.1042/BSR20203248
PMCID: PMC7786326

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