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Article

Enzymatic characterization and mutational studies of TruD--the fifth family of pseudouridine synthases.

Archives of biochemistry and biophysics - 1 Sept 2009

Chan Chio Mui, Huang Raven H

Abstract excerpt

Pseudouridine (Psi) is formed through isomerization of uridine (U) catalyzed by a class of enzymes called pseudouridine synthases (PsiS). TruD is the fifth family of PsiS. Studies of the first four families (TruA, TruB, RsuA, and RluA) of PsiS reveal a conserved Asp and Tyr are critical for catalysis. However, in TruD family, the tyrosine is not conserved. In this study, we measured the enzymatic parameters for...

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Identifiers

PMID: 19664587
DOI: 10.1016/j.abb.2009.07.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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