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Article

Association between dense CADM1 promoter methylation and reduced protein expression in high‐grade CIN and cervical SCC

17 Apr 2008

Abstract excerpt

We previously showed that silencing of TSLC1, recently renamed CADM1, is functionally involved in high-risk HPV-mediated cervical carcinogenesis. CADM1 silencing often results from promoter methylation. Here, we determined the extent of CADM1 promoter methylation in cervical (pre)malignant lesions and its relation to anchorage-independent growth and gene silencing to select a CADM1-based methylation marker for...

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PMID: 18498117
DOI: 10.1002/path.2367

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