Article
The Neandertal genome and ancient DNA authenticity.
The EMBO journal - 2 Sept 2009
Green Richard E, Briggs Adrian W, Krause Johannes, Prüfer Kay, Burbano Hernán A, Siebauer Michael, Lachmann Michael, Pääbo Svante
Abstract excerpt
Recent advances in high-thoughput DNA sequencing have made genome-scale analyses of genomes of extinct organisms possible. With these new opportunities come new difficulties in assessing the authenticity of the DNA sequences retrieved. We discuss how these difficulties can be addressed, particularly with regard to analyses of the Neandertal genome. We argue that only direct assays of DNA sequence positions in...
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