Article
Targeted retrieval and analysis of five Neandertal mtDNA genomes.
Science (New York, N.Y.) - 17 Jul 2009
Briggs Adrian W, Good Jeffrey M, Green Richard E, Krause Johannes, Maricic Tomislav, Stenzel Udo, Lalueza-Fox Carles, Rudan Pavao, Brajkovic Dejana, Kucan Zeljko, Gusic Ivan, Schmitz Ralf, Doronichev Vladimir B, Golovanova Liubov V, de la Rasilla Marco, Fortea Javier, Rosas Antonio, Pääbo Svante
Abstract excerpt
Analysis of Neandertal DNA holds great potential for investigating the population history of this group of hominins, but progress has been limited due to the rarity of samples and damaged state of the DNA. We present a method of targeted ancient DNA sequence retrieval that greatly reduces sample destruction and sequencing demands and use this method to reconstruct the complete mitochondrial DNA (mtDNA) genomes of...
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